Category: mental health

  • The dopamine gold rush: How bad habits are formed and kept

    By JayDee Vykoukal

    In September of 2024, researchers at the University of Central Florida ( UCF ) unveiled a rapid test sensor to detect dopamine in our system. The device will increase the detection of neurological diseases and cancers caused by too much or too little of this important brain chemical.

    Dopamine is a neural transmitter that regulates feelings of reward or pleasure. The UCF team, led by Professor Debashis Chanda, developed an “integrated optical sensor” able to detect the important brain chemical from unprocessed blood.

    The sensor uses a synthetic DNA strand, known as an aptamer, to identify the dopamine present in a person’s system.

    Dopamine’s Role in Society

    While this is good news for the neuroscience community, dopamine has had negative headlines of late. The neurochemical is an essential part of the human condition, though it also leads to forming habits — namely bad ones.

    Dopamine plays a huge part in our brain development, not least when we display destructive, repeated behavior. In Atomic Habits, author James Clear gives a detailed breakdown of all the neuroscience involved in habit formation, or what he calls the “habit loop.”

    How Habits Form

    Within the habit loop, Clear lists three core elements:

    Cue (The Trigger). Habit loops begin with a trigger for behavior: extrinsic or intrinsic signals that prompt a habitual response. Certain brain regions, like the basal ganglia, are where this interplay takes place. Routine (The Behavior). The next part of a habit loop is when it becomes routine — our decision-making process carries out this stage, guided by the prefrontal cortex. Routines will embed as neural pathways become active; these strengthen through a reaction known as long-term potentiation (LTP).Reward (The Reinforcement). Finally, dopamine gets to work in the reward phase, where the routine culminates. Dopamine governs how we feel rewarded, bolstering the habit loop and ensuring repeated behavior in the future.

    Distraction vs. Entertainment

    American cultural polemicist and music historian Ted Gioia likes to use the term “dopamine culture” to portray his worldview. His essay, “The State of the Culture, 2024,” published earlier this year, reads like a societal eulogy.

    Gioia believes we are seeing a “post-entertainment culture” emerge from the ashes of its previous glory. In his opinion, distraction has now taken over from arts and entertainment, and the distraction industry is here to stay.

    “This is more than just the hot trend of 2024,” writes Gioia. “It can last forever — because it’s based on body chemistry, not fashion or aesthetics.

    Where in the past, the emphasis was on keeping people awed or entertained, the present points to a new goal — addiction. “Everything is designed to lock users into an addictive cycle,” writes Gioia. “This is present in everyday life, not least our cell phones.”

    Fishing for Users

    While social media platforms fish for more subscribers, the psychological methods they use are what keep users hooked. The International Journal of Environmental Science and Public Health published a 2019 study on modern tech’s addictive features.

    The study points to how the exchange of personal data fuels a string of measures used within “Freemium” online games and social media apps. Researchers analyzed “several prominent smartphone apps” to uncover these methods.

    Addictive by Design

    Scientists highlighted at least six different mechanisms used in prevailing smartphone app development, with some classic psychological/economic theories present:

    — Endless scrolling. Once a video or post has finished, something similar appears underneath, tempting the user with more content.

    — Social comparison and social reward, which usually means a “like” on a social media post;

    — The endowment effect — or our hard-wired tendency to give personal belongings higher value than others. Once an app user has built a profile, added their preferences, and attached meaningful posts, they will be less likely to discard the app.

    — The mere-exposure effect, which is a form of cognitive bias in which people indicate a preference for something they find familiar; Social pressure. In apps like WhatsApp, the sender will see two gray ticks appear under a message they sent. These ticks turn blue when the recipient reads the message, putting them on a perceived time trial for responding.

    — The Zeigarnik effect refers to the human ability to remember unfinished tasks. This technique is especially powerful on social media platforms, where messaging or commenting makes up most of the activity.

    At the very least, apps’ success relies on showing users what they like to see. One example of this is a personalized news feed catering to a singular worldview. Algorithms reward the user with similar content to what they’ve seen before. This maneuver makes them feel more connected to their app and less inclined to switch off.

    Childhood Habits Have Become Untenable

    Social psychologist and author Jonathan Heidt has studied the phenomenon of smartphone technology and behavior extensively. In an Atlantic article titled “End the Phone-Based Childhood Now,” Heidt outlines how smartphones have laid waste to America’s youth.

    He cites one overwhelming consequence of teenage smartphone addiction: a precipitous rise in depression and anxiety. Suicide rates in American adolescents aged between 10 and 19 went up by half between 2010 and 2019. Just for girls between 10 and 14 years, the rate increased a shocking 131%.

    Falling Grades and Rising Depression

    Other implications include surging rates of isolation and a decline in academic achievement. All of these changes came when social media platforms were emerging into everyday life. What’s perhaps most startling is how both teen suicide rates and academic prowess were improving through the 2000s in America.

    The Nation’s Report Card published U.S. reading and math scores over the past few decades, cementing Heidt’s concerns. Both scores peaked in 2012, though they have each fallen in the years since. Clearly, bad habits are taking over in age groups where they shouldn’t be.

    The modern era is now rife with dopamine-inducing temptations wherever one turns. Ads for food and cookery influencers create content that might elicit binge eating. Moreover, news and short-form video platforms like YouTube Shorts allow vicarious — and often negative — viewing experiences, prompting unhealthy doom-scrolling.

    Rewiring the Habit Loop

    Of course, there is much conversation on this matter, with terminology to match. University of California, San Francisco Medical School professor Dr. Cameron Sepah is responsible for the term “dopamine fasting.”

    Sepah writes on his LinkedIn page how his “Dopamine Fasting 2.0” is an “evidence-based technique to manage addictive behaviors, by restricting them to specific periods of time…” His objective is for people to “regain behavioral flexibility” by fasting from impulsive choices.

    Fighting the Urge

    The method is a cognitive-behavioral therapy (CBT) driven process he calls “stimulus control.” Putting one’s phone away is the first step, followed by finding a less sedentary alternative to combat the urge to retrieve it. Finally, blocking the apps, platforms, or video games causing the problem is another suggested measure.

    Sepah also recommends “urge surfing,” wherein one reflects on the desire to repeat the habit in question, watching it “come and go.” By training oneself to understand why negative impulses occur, Sepah believes people can help weaken habituation, replacing bad habits with good ones.

    JayDeeVykoukal is the author of this article, a Doctor of Physical Therapy, a travel enthusiast, and a mom of two girls. Having completed her Doctorate of Physical Therapy at the University of Montana in 2013, Jay Dee has sought to combine her passion for health and wellness with her love for traveling and writing. She is an avid traveler who has visited over 30 countries.

    Jay Dee’s writing reflects her diverse passions for physical therapy, holistic health, travel, and parenting. She writes about everything from tips on injury prevention to gardening, science facts, and fun places to visit around the globe with children in tow. Jay Dee hopes to share her knowledge with others through her books and blogs so they can live happier, more meaningful, and healthier lives.

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  • Developing a vaccine for the “zombie drug” xylazine

    Scripps Research chemical biologists design an early “proof-of-concept” vaccine that could lead to the first effective treatment of xylazine overdose in people.

    “Evaluation of a Hapten Conjugate Vaccine Against the ‘Zombie Drug’ Xylazine” was co-authored by Mingliang Lin, Lisa M. Eubanks, Bin Zhou, and Kim D. Janda, all of Scripps Research.

    April 03, 2024


    LA JOLLA, CA—Xylazine is an FDA-approved sedative and pain reliever for use in animals, but it has severe adverse effects when used in humans. It is now illicitly being added to opioids, like fentanyl and heroin, as well as cocaine—leading to a sharp rise in overdose deaths.

    Now, Scripps Research chemical biologists have developed a vaccine to block the effects of xylazine’s toxicity. The vaccine works by training the immune system to attack the drug, which is described in a new paper published in Chemical Communications on April 1, 2024.

    “We demonstrated that a vaccine can reverse the symptoms of a xylazine overdose in rodents,” says study senior author Kim D. Janda, PhD, the Ely R. Callaway, Jr. Professor of Chemistry at Scripps Research. “There is currently no remedy for xylazine poisoning other than supportive care, thus, we believe our research efforts and the data we have provided will pave the way for an effective treatment in humans.”

    The rapid increase in lethal drug overdoses attributed to xylazine combined with fentanyl prompted the White House Office of National Drug Control Policy to declare this combination an emerging threat to the United States. Xylazine intoxication presents similarly to opioid overdose, causing respiratory and central nervous system depression, and it can heighten the effects of opioids. However, naloxone—typically administered to reverse the effects of opioids—does not tackle the impact of xylazine, highlighting the need for effective measures to treat acute toxicity caused by xylazine.

    Researchers suspect xylazine works by reducing blood flow to the brain, among other areas of the body. The drug also causes non-healing skin lesions and wounds, often located on the forearms and lower legs, that can require amputation in some cases—giving it the nickname “zombie drug.”

    Although no treatment currently exists, targeted vaccines may offer a solution. Vaccines nudge the immune system to create antibodies to fend off invaders. Antibodies can target viruses, bacteria and toxins. However, sometimes molecules are too small to initiate an immune response, as is the case with xylazine. So, to circumvent this problem, the researchers created a vaccine using a design principle that Janda pioneered, which relies on pairing the drug molecule (called a hapten) with a larger carrier molecule (a protein) and an adjuvant.

    In this study, the scientists combined a xylazine hapten with multiple different protein types, to see which combination would create a robust immune response against xylazine. The team tested three vaccine formulations (termed TT, KLH and CRM197, based on the protein involved) to see which vaccine cocktail could help rodents after being challenged with xylazine. One of the three vaccines (TT) significantly increased movement in mice given xylazine after 10 minutes, while two of the three vaccines (TT and KLH) led to an improvement in breathing.

    The scientists also examined how these vaccines would limit xylazine blood brain barrier, (BBB) permeation, a filtering mechanism that scrutinizes drug penetration. When xylazine was injected, it immediately crossed into the brain to bind with receptors. Antibodies typically cannot navigate the BBB; however, two of the three vaccines (TT and KLH) showed a strong ability to stop xylazine from reaching its receptors in the brain, limiting its detrimental effects.

    A provisional patent has been filed on the research. In the future, his team will build off this work to create a bifunctional antibody that will reverse both fentanyl and xylazine’s toxicity simultaneously, something that naloxone cannot do.

    “A monoclonal antibody treatment could be given in tandem with the vaccine to provide both immediate and long-term protection from both opioid substance use disorders as well as opioid-xylazine overdoses,” says Janda. “This strategy could make a significant impact on the opioid epidemic.”  

    Funding for the study was provided by the Shadek family and Pearson Foundation.

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  • What Is Sex Addiction?

    If you’re a sex addict, you’re dealing with an escalating, obsessive preoccupation with sexual fantasy and behaviors. As a result, you’ve damaged your romantic relationships, career, education, friendships, finances, and other life priorities. Most likely, you use the intensity of sexual fantasy and behaviors to escape (to avoid feeling) emotional discomfort – stress, anxiety, loneliness, depression, shame, boredom, and the like.

    Are you obsessively preoccupied with sex?

    Have you tried and failed to cut back or quit your involvement with porn, hookup apps, strip clubs, prostitution, affairs, compulsive masturbation, voyeurism, or similar behaviors?

    Are you experiencing negative consequences related to your out-of-control sex life?

    If you think you or a loved one may be struggling with sex addiction, we suggest you take this anonymous 25-question screening test:

    Sex and Porn Addiction Self-Test. 

    This Sex and Porn Addiction Self-Test is a preliminary assessment tool. Your answers to the questions in this short quiz can help you, in conjunction with a licensed psychotherapist, identify issues that you may have with sex or porn addiction. Answer each question by circling the appropriate response- “yes” or “no” .

    1. Do you feel overly distracted by, obsessed with, or preoccupied by your sexual fantasies and behavior?

     Yes

     No

    2. Do you ever have trouble stopping your sexual behavior, even when you have more important things to do?

     Yes

     No

    3. After having sex (with self or others), do you sometimes feel depressed or regret it?

     Yes

     No

    4. Have you made promises to yourself or another person to change aspects of your sexual behavior, only to break those promises later?

     Yes

     No

    5. Did you experience abuse, neglect, or other serious trauma as a child or adolescent?

     Yes

     No

    6. Do you look forward to events with family and/or friends being over so you can engage in sexual behavior?

     Yes

     No

    7. Do you have trouble maintaining relationships once the sexual newness and intensity has worn off?

     Yes

     No

    8. Have you ever kept secrets or lied about money and/or time spent on sex, porn, affairs, and similar behavior?

     Yes

     No

    9. Do you sometimes regret the amount of time you spend with porn, webcams, hookup apps, and other forms of tech-driven sexual behavior?

     Yes

     No

    10. Does your sexual behavior, real-world or online, interfere with your personal goals or create negative consequences in your work, community, or academic life?

     Yes

     No

    11. Have your family, friends, or partner(s) ever worried or complained about your sexual behavior?

     Yes

     No

    12. Does your sexual behavior potentially offend others, violate community standards, or place you in danger of arrest?

     Yes

     No

    13. Do you ever find yourself “lost” in sexual fantasies and behavior as a way of coping with stress, boredom, loneliness, or other forms of emotional discomfort?

     Yes

     No

    14. Do you keep certain elements of your sexual behavior hidden from partners and/or friends?

     Yes

     No

    15. Do you believe that porn use, casual sex, and similar behavior may have kept you from creating and maintaining a successful long-term intimate relationship?

     Yes

     No

    16. Have you repeatedly engaged in unsafe or “risky” sex?

     Yes

     No

    17. Have you had certain kinds of sex (alone or with a partner) that you later regretted?

     Yes

     No

    18. Does your sexual behavior ever leave you worried about or at risk of contracting or sharing sexually transmitted diseases?

     Yes

     No

    19. Do you find yourself feeling restless, irritable, or discontented when you are unable to engage in certain sexual fantasies and activities?

     Yes

     No

    20. Has your involvement with porn, hookup apps, sex/dating websites, and other online sexual environments become greater than your intimate contact with romantic partners?

     Yes

     No

    21. Has anyone ever been hurt by lies and secrets related to your sexual behavior?

     Yes

     No

    22. Do you ever feel compelled to seek out porn, hookups, and other forms of sexual activity, online or real world, even though you are trying to stop these behaviors?

     Yes

     No

    23. Has the nature and/or intensity of your sexual fantasies and behavior escalated over time?

     Yes

     No

    24. Do you find that you spend more time with sexual fantasies and behavior than you would like?

     Yes

     No

    25. Have you ever been approached by the police, arrested, or charged with a crime related to your sexual behavior?

     Yes

     No

    Scoring-

    An overwhelming percentage of positive answers is an indication you should be discussing your behavior with a therapist. A Certified Sex Addiction Therapist (CSAT after their name) or a Certified Christian Sex Addiction Specialist is trained and qualified to treat individuals with compulsive sexual disorders and trauma resulting from sexual abuse.

    Perhaps you are a concerned significant other, spouse or relative of a sex addict. You also have clinical professionals trained to assist you in your healing journey. Certified Clinical Partner Specialists (CCPS after the professional’s name) or a member of the Association for Partners of Sex Addicts Trauma Specialists (APSATS) have been trained in the treatment of partners of sex addicts. When seeking a clinical professional knowledgeable in sex addiction, ask questions about the training of the psychotherapist or other helping professional. Substance addiction training does not qualify a clinical professional to treat a compulsive sexual disorder.

    An affirmative answer to question #12 or #25, regarding illegal sexual behavior, is always a problem. If you answered yes to either of these questions, learn about the mandated reporting laws in your state before speaking to a professional about your challenges. Then , you should seek confidential advice from a licensed professional skilled in handling the disclosure of illegal compulsive sexual actions. Be aware that psychotherapists and other helping professionals (including clerics and lawyers) may have reporting requirements (that can vary from state to state) related to illegal sexual behaviors. Please learn about the reporting laws in your state before speaking to a professional in detail about your challenges.

    If you have attempted stopping this behavior on your own but have been unsuccessful and you think you need a break and focus on more concentrated help, look into an inpatient residential program for sex addiction. The Meadows- Gentle Path, Pine Grove Behavioral Health & Addiction Services, Keystone ECU, Seeking Integrity, and Blue Tiger Recovery are inpatient residential programs with excellent reputations.

    This Self-Assessment’s original version was written by Robert Weiss, PhD., and Patrick J. Carnes, PhD., in 2010. This version’s Copyright © 2018, Seeking Integrity LLC, Robert Weiss, PhD

    To ask Seeking Integrity About Treatment, Call  (747) 234-HEAL (4325)

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