Category: Addiction

  • The dopamine gold rush: How bad habits are formed and kept

    By JayDee Vykoukal

    In September of 2024, researchers at the University of Central Florida ( UCF ) unveiled a rapid test sensor to detect dopamine in our system. The device will increase the detection of neurological diseases and cancers caused by too much or too little of this important brain chemical.

    Dopamine is a neural transmitter that regulates feelings of reward or pleasure. The UCF team, led by Professor Debashis Chanda, developed an “integrated optical sensor” able to detect the important brain chemical from unprocessed blood.

    The sensor uses a synthetic DNA strand, known as an aptamer, to identify the dopamine present in a person’s system.

    Dopamine’s Role in Society

    While this is good news for the neuroscience community, dopamine has had negative headlines of late. The neurochemical is an essential part of the human condition, though it also leads to forming habits — namely bad ones.

    Dopamine plays a huge part in our brain development, not least when we display destructive, repeated behavior. In Atomic Habits, author James Clear gives a detailed breakdown of all the neuroscience involved in habit formation, or what he calls the “habit loop.”

    How Habits Form

    Within the habit loop, Clear lists three core elements:

    Cue (The Trigger). Habit loops begin with a trigger for behavior: extrinsic or intrinsic signals that prompt a habitual response. Certain brain regions, like the basal ganglia, are where this interplay takes place. Routine (The Behavior). The next part of a habit loop is when it becomes routine — our decision-making process carries out this stage, guided by the prefrontal cortex. Routines will embed as neural pathways become active; these strengthen through a reaction known as long-term potentiation (LTP).Reward (The Reinforcement). Finally, dopamine gets to work in the reward phase, where the routine culminates. Dopamine governs how we feel rewarded, bolstering the habit loop and ensuring repeated behavior in the future.

    Distraction vs. Entertainment

    American cultural polemicist and music historian Ted Gioia likes to use the term “dopamine culture” to portray his worldview. His essay, “The State of the Culture, 2024,” published earlier this year, reads like a societal eulogy.

    Gioia believes we are seeing a “post-entertainment culture” emerge from the ashes of its previous glory. In his opinion, distraction has now taken over from arts and entertainment, and the distraction industry is here to stay.

    “This is more than just the hot trend of 2024,” writes Gioia. “It can last forever — because it’s based on body chemistry, not fashion or aesthetics.

    Where in the past, the emphasis was on keeping people awed or entertained, the present points to a new goal — addiction. “Everything is designed to lock users into an addictive cycle,” writes Gioia. “This is present in everyday life, not least our cell phones.”

    Fishing for Users

    While social media platforms fish for more subscribers, the psychological methods they use are what keep users hooked. The International Journal of Environmental Science and Public Health published a 2019 study on modern tech’s addictive features.

    The study points to how the exchange of personal data fuels a string of measures used within “Freemium” online games and social media apps. Researchers analyzed “several prominent smartphone apps” to uncover these methods.

    Addictive by Design

    Scientists highlighted at least six different mechanisms used in prevailing smartphone app development, with some classic psychological/economic theories present:

    — Endless scrolling. Once a video or post has finished, something similar appears underneath, tempting the user with more content.

    — Social comparison and social reward, which usually means a “like” on a social media post;

    — The endowment effect — or our hard-wired tendency to give personal belongings higher value than others. Once an app user has built a profile, added their preferences, and attached meaningful posts, they will be less likely to discard the app.

    — The mere-exposure effect, which is a form of cognitive bias in which people indicate a preference for something they find familiar; Social pressure. In apps like WhatsApp, the sender will see two gray ticks appear under a message they sent. These ticks turn blue when the recipient reads the message, putting them on a perceived time trial for responding.

    — The Zeigarnik effect refers to the human ability to remember unfinished tasks. This technique is especially powerful on social media platforms, where messaging or commenting makes up most of the activity.

    At the very least, apps’ success relies on showing users what they like to see. One example of this is a personalized news feed catering to a singular worldview. Algorithms reward the user with similar content to what they’ve seen before. This maneuver makes them feel more connected to their app and less inclined to switch off.

    Childhood Habits Have Become Untenable

    Social psychologist and author Jonathan Heidt has studied the phenomenon of smartphone technology and behavior extensively. In an Atlantic article titled “End the Phone-Based Childhood Now,” Heidt outlines how smartphones have laid waste to America’s youth.

    He cites one overwhelming consequence of teenage smartphone addiction: a precipitous rise in depression and anxiety. Suicide rates in American adolescents aged between 10 and 19 went up by half between 2010 and 2019. Just for girls between 10 and 14 years, the rate increased a shocking 131%.

    Falling Grades and Rising Depression

    Other implications include surging rates of isolation and a decline in academic achievement. All of these changes came when social media platforms were emerging into everyday life. What’s perhaps most startling is how both teen suicide rates and academic prowess were improving through the 2000s in America.

    The Nation’s Report Card published U.S. reading and math scores over the past few decades, cementing Heidt’s concerns. Both scores peaked in 2012, though they have each fallen in the years since. Clearly, bad habits are taking over in age groups where they shouldn’t be.

    The modern era is now rife with dopamine-inducing temptations wherever one turns. Ads for food and cookery influencers create content that might elicit binge eating. Moreover, news and short-form video platforms like YouTube Shorts allow vicarious — and often negative — viewing experiences, prompting unhealthy doom-scrolling.

    Rewiring the Habit Loop

    Of course, there is much conversation on this matter, with terminology to match. University of California, San Francisco Medical School professor Dr. Cameron Sepah is responsible for the term “dopamine fasting.”

    Sepah writes on his LinkedIn page how his “Dopamine Fasting 2.0” is an “evidence-based technique to manage addictive behaviors, by restricting them to specific periods of time…” His objective is for people to “regain behavioral flexibility” by fasting from impulsive choices.

    Fighting the Urge

    The method is a cognitive-behavioral therapy (CBT) driven process he calls “stimulus control.” Putting one’s phone away is the first step, followed by finding a less sedentary alternative to combat the urge to retrieve it. Finally, blocking the apps, platforms, or video games causing the problem is another suggested measure.

    Sepah also recommends “urge surfing,” wherein one reflects on the desire to repeat the habit in question, watching it “come and go.” By training oneself to understand why negative impulses occur, Sepah believes people can help weaken habituation, replacing bad habits with good ones.

    JayDeeVykoukal is the author of this article, a Doctor of Physical Therapy, a travel enthusiast, and a mom of two girls. Having completed her Doctorate of Physical Therapy at the University of Montana in 2013, Jay Dee has sought to combine her passion for health and wellness with her love for traveling and writing. She is an avid traveler who has visited over 30 countries.

    Jay Dee’s writing reflects her diverse passions for physical therapy, holistic health, travel, and parenting. She writes about everything from tips on injury prevention to gardening, science facts, and fun places to visit around the globe with children in tow. Jay Dee hopes to share her knowledge with others through her books and blogs so they can live happier, more meaningful, and healthier lives.

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  • Developing a vaccine for the “zombie drug” xylazine

    Scripps Research chemical biologists design an early “proof-of-concept” vaccine that could lead to the first effective treatment of xylazine overdose in people.

    “Evaluation of a Hapten Conjugate Vaccine Against the ‘Zombie Drug’ Xylazine” was co-authored by Mingliang Lin, Lisa M. Eubanks, Bin Zhou, and Kim D. Janda, all of Scripps Research.

    April 03, 2024


    LA JOLLA, CA—Xylazine is an FDA-approved sedative and pain reliever for use in animals, but it has severe adverse effects when used in humans. It is now illicitly being added to opioids, like fentanyl and heroin, as well as cocaine—leading to a sharp rise in overdose deaths.

    Now, Scripps Research chemical biologists have developed a vaccine to block the effects of xylazine’s toxicity. The vaccine works by training the immune system to attack the drug, which is described in a new paper published in Chemical Communications on April 1, 2024.

    “We demonstrated that a vaccine can reverse the symptoms of a xylazine overdose in rodents,” says study senior author Kim D. Janda, PhD, the Ely R. Callaway, Jr. Professor of Chemistry at Scripps Research. “There is currently no remedy for xylazine poisoning other than supportive care, thus, we believe our research efforts and the data we have provided will pave the way for an effective treatment in humans.”

    The rapid increase in lethal drug overdoses attributed to xylazine combined with fentanyl prompted the White House Office of National Drug Control Policy to declare this combination an emerging threat to the United States. Xylazine intoxication presents similarly to opioid overdose, causing respiratory and central nervous system depression, and it can heighten the effects of opioids. However, naloxone—typically administered to reverse the effects of opioids—does not tackle the impact of xylazine, highlighting the need for effective measures to treat acute toxicity caused by xylazine.

    Researchers suspect xylazine works by reducing blood flow to the brain, among other areas of the body. The drug also causes non-healing skin lesions and wounds, often located on the forearms and lower legs, that can require amputation in some cases—giving it the nickname “zombie drug.”

    Although no treatment currently exists, targeted vaccines may offer a solution. Vaccines nudge the immune system to create antibodies to fend off invaders. Antibodies can target viruses, bacteria and toxins. However, sometimes molecules are too small to initiate an immune response, as is the case with xylazine. So, to circumvent this problem, the researchers created a vaccine using a design principle that Janda pioneered, which relies on pairing the drug molecule (called a hapten) with a larger carrier molecule (a protein) and an adjuvant.

    In this study, the scientists combined a xylazine hapten with multiple different protein types, to see which combination would create a robust immune response against xylazine. The team tested three vaccine formulations (termed TT, KLH and CRM197, based on the protein involved) to see which vaccine cocktail could help rodents after being challenged with xylazine. One of the three vaccines (TT) significantly increased movement in mice given xylazine after 10 minutes, while two of the three vaccines (TT and KLH) led to an improvement in breathing.

    The scientists also examined how these vaccines would limit xylazine blood brain barrier, (BBB) permeation, a filtering mechanism that scrutinizes drug penetration. When xylazine was injected, it immediately crossed into the brain to bind with receptors. Antibodies typically cannot navigate the BBB; however, two of the three vaccines (TT and KLH) showed a strong ability to stop xylazine from reaching its receptors in the brain, limiting its detrimental effects.

    A provisional patent has been filed on the research. In the future, his team will build off this work to create a bifunctional antibody that will reverse both fentanyl and xylazine’s toxicity simultaneously, something that naloxone cannot do.

    “A monoclonal antibody treatment could be given in tandem with the vaccine to provide both immediate and long-term protection from both opioid substance use disorders as well as opioid-xylazine overdoses,” says Janda. “This strategy could make a significant impact on the opioid epidemic.”  

    Funding for the study was provided by the Shadek family and Pearson Foundation.

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  • Every Narcissist needs a Codependent Love Addict

    “The most common toxic relationship is between the codependent love addict and the narcissist love addict. Opposites attract and love addicts are vulnerable to charming people.” -Author, therapist and founder of Love Addicts Anonymous, Susan Peabody.

    Narcissism is a personality disorder. It stems from childhood abuse. When these abused children are young, they decide that the world, and the people in it, are bad and they are the only ones that are good. These thoughts result in a distorted view of themselves. They are the ones that are perfect, and they should be catered to. They lack compassion for others because everyone else is ‘less than or wrong. In general, narcissists are incapable of maintaining a healthy relationship because they have to be in control at all times.

    But really, a narcissist has to be in control because they experienced the trauma of not being in control, being abused, abandoned, or made to feel ‘less than’ at a young age. In order to feel they are not being abandoned, abused, thwarted, or hurt they have chosen to put on false bravado, to dominate, and/or exhibit righteousness to protect their damaged “inner child” from being seen.

    These narcissistic behaviors hide the fact there is a hurt child and in its place is this thoroughly in control adult-child, which is what the young child assumes their parent wants and will love. This becomes a belief of “You will love me because I am in control.” This behavior finds a home in any gender; male or female, non-binary, trans, or any sexual preference; heterosexual, gay, bisexual, and in any type of relationship; collegial, familiar, or intimate.

    If you keep your eyes open, you can detect a narcissist’s need for control and self-centeredness. If you make an error, they will be critical and unsympathetic. A narcissist will never forget a past mistake. They hold you to a high standard and exhibit disdain for what they consider weakness or vulnerability.

    Narcissists are very charming in order to seduce people into liking them. Their ability to impress people is amazing. They appear confident, exciting and are a “match made in heaven”. Love addicts fall for narcissists and bond with them. Narcissists are so good at their craft, that when their true colors emerge, they manipulate their codependent love addict partner to ensure they will not abandon them.

    A codependent love addict fears abandonment as much as the narcissist

    It is as if the narcissist and codependent love addict are fighting for the same thing. The codependent love addict fears abandonment as much as the narcissist. Early abandonment of a child places that kid into a very harsh environment, forcing them to figure out a way to survive. They hate the fact they were abandoned but believe that they can endure, and if they work hard enough, to prove their worth, their parent (or love interest) will not abandon them, thus ensuring abandonment will never happen to them again. This becomes a belief of” You will love me because I will do for you before I do for myself.”A codependent love addict adult emerges from this traumatic early childhood experience.

    Narcissists and codependent love addicts are trauma survivors

    Both narcissists and codependent love addicts are survivors. A narcissist will overwork in order to get what they need to survive. A codependent will scrape and do without in order for their offspring and family to survive. Both of these behavioral types excel in sales, in service positions, or dealing with the public. If they need more money than a 9-5 career can provide, they overwork. We will find them at a grocery store stocking shelves at midnight or selling craft goods on Etsy. The narcissist will make demands to the codependent to do ‘more for me’ or ‘love me more.’

    The codependent love addicts are constantly fulfilling their role as the primary enabler for their narcissists. A consummate “make doer”, the codependent is unable to speak up for themselves, selling themselves short in order to avoid the pain of conflict with their loved one. Both are strong and resilient, yet mute to the need for resolution of the inner turmoil surrounding their early, adverse childhood traumas.

    You might want to consider attending a 12 step mutual support group such as:

    http://www.loveaddicts.org/

    http://www.slaafws.org

    http://coda.org/

    http://www.adultchildren.org/

    To find a professional with counseling experience in love addiction go to the Society for the Advancement of Sexual Health (SASH), which is a nonprofit organization dedicated to scholarship and training of professionals certified in sex and love addiction treatment.

    For training and to find a professional with counseling experience in trauma, and love addiction consider the International Institute for Trauma and Addiction Professionals (IITAP) which is a resource for therapists specializing in the areas of sex addiction recovery and trauma.

    Other good books and resources are:

    We Codependent Men – We Mute Coyotes: Hope, Inspiration, and Healing for Men Living with Addicted People by Ken P, Bob T

    Codependents No More- Codependents’ Guide: Heal Yourself After a Toxic Relationship, Overcome Jealousy, Possessiveness, Anxiety, and Boost your Self-Esteem

    Codependent Mother: Codependency Cycle Recovery for a Daughter. No more Toxic Emotional Abuse in Family Relationships. A Guide to Cure Afflictions and Healing your Self-Esteem by Dana Jackson

    The New Codependency: Help and Guidance for Today’s Generation by Melody Beattie

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